DACH2

Across TCGA pan-cancer cohorts, DACH2 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated DACH2 data layer compared with 19 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DACH2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DACH2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

HNSC, LUSC, and CESC are the cancer types where DACH2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.218	0.663	<.001	30	view →
LUSC	DFS	Median	All	0.481	0.769	<.001	28	view →
CESC	OS	Median	III,IV	0.095	0.755	<.001	18	view →
ACC	OS	Median	All	0.273	0.802	.017	15	view →
LAML	DFS	Median	All	0.111	0.572	.010	12	view →
PRAD	DFS	Median	All	0.474	0.888	<.001	6	view →
UCEC	DFS	Median	All	0.920	0.622	.017	6	view →
SKCM	OS	Median	IV	0.415	0.861	.014	6	view →
LUAD	OS	Median	All	0.675	0.336	.013	5	view →
STAD	OS	Median	II,III,IV	0.367	0.579	.048	3	view →
COAD	DFS	Median	All	1.000	0.505	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

DACH2–HNSC (OS)

Open the HNSC breakdown →