DACH2

Across TCGA patient cohorts, DACH2 mutation is significantly associated with the RNA expression of many other genes, with 4,073 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DACH2-associated genes across cancer lineages are CD207, PSMC3IP, and ACKR3. Each is linked with DACH2 in more than 3 cancer types. Because this analysis shows association rather than direction, both DACH2-to-partner and partner-to-DACH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD207 grouped by DACH2-low versus DACH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DACH2→partner) and Y-score (partner→DACH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD207 →	-0.806	-3.512	<.001	<.001	3	4
UCEC	PSMC3IP →	+0.540	+2.413	<.001	<.001	3	4
STAD	ACKR3 →	-0.634	-2.271	.006	.006	3	4
STAD	ADAM33 →	-0.986	-3.459	.001	.005	3	4
UCEC	CDC45 →	+0.658	+1.731	<.001	<.001	3	4
UCEC	ZNHIT3 →	+0.323	+1.699	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,073 associations by consensus.

CD207 by DACH2 expression — UCEC

Explore this box plot interactively →