DACH2

Across TCGA cell cohorts, DACH2 RNA expression is significantly associated with the go_rna of many other GO terms, with 271 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible DACH2-associated GO terms across cancer lineages are Zymogen activation, Regulation of protein localization to membrane, and Negative regulation of actin filament polymerization. Each is linked with DACH2 in more than 4 cancer types. Because this analysis shows association rather than direction, both DACH2-to-partner and partner-to-DACH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Zymogen activation grouped by DACH2-low versus DACH2-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DACH2→partner) and Y-score (partner→DACH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Zymogen activation →	-0.072	-0.294	.002	.007	2	5
OVARY	Regulation of protein localization to membrane →	-0.055	-0.149	<.001	.006	3	4
OVARY	Negative regulation of actin filament polymerization →	-0.120	-0.223	<.001	.005	3	3
OVARY	Response to ketone →	-0.093	-0.191	<.001	.007	3	3
OVARY	Mononuclear cell differentiation →	-0.035	-0.149	<.001	.006	3	3
OVARY	Hypothalamus cell differentiation →	-0.477	-0.155	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 271 associations by consensus.

Zymogen activation by DACH2 expression — BLOOD_Myeloma

Explore this box plot interactively →