DACH1

Across TCGA patient cohorts, DACH1 protein abundance is significantly associated with the RNA expression of many other genes, with 9,961 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible DACH1-associated genes across cancer lineages are RPL35AP31, WFS1, and RPL21P109. Each is linked with DACH1 in more than 4 cancer types. Because this analysis shows association rather than direction, both DACH1-to-partner and partner-to-DACH1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DACH1 versus RPL35AP31 in GBM, with a Pearson correlation of 0.83.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DACH1→partner) and Y-score (partner→DACH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPL35AP31 →	+2.532	+1.502	<.001	<.001	3	5
BRCA	WFS1 →	+0.988	+0.663	<.001	<.001	3	4
UCEC	RPL21P109 →	+1.472	+0.910	<.001	<.001	3	4
UCEC	TCF4-AS1 →	+0.664	+0.664	.005	.001	3	4
LSCC	FENDRR →	+0.830	+0.483	<.001	<.001	3	4
UCEC	CCL20 →	-1.260	-0.528	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,961 associations by consensus.

DACH1 vs RPL35AP31 — GBM

Explore this scatter interactively →