DACH1

Across TCGA patient cohorts, DACH1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DACH1-associated genes across cancer lineages are Cyclin-B1, MSH6, and MSH2. Each is linked with DACH1 in more than 3 cancer types. Because this analysis shows association rather than direction, both DACH1-to-partner and partner-to-DACH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by DACH1-low versus DACH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DACH1→partner) and Y-score (partner→DACH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.611	+1.584	.002	.019	1	4
LUAD	MSH6 →	+0.348	+2.000	.006	.031	3	2
UCEC	MSH2 →	-0.246	-1.848	.003	.049	3	2
UCEC	Annexin-1 →	+0.709	+2.926	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.456	+2.019	.033	.017	3	2
UCEC	4E-BP1 →	+0.431	+3.807	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Cyclin-B1 by DACH1 expression — UCEC

Explore this box plot interactively →