DACH1

Across TCGA cell cohorts, DACH1 mutation is significantly associated with the RNA expression of many other genes, with 332 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DACH1-associated genes across cancer lineages are CTNNA1, COA7, and ZNF669. Each is linked with DACH1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DACH1-to-partner and partner-to-DACH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CTNNA1 grouped by DACH1-low versus DACH1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DACH1→partner) and Y-score (partner→DACH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CTNNA1 →	-0.662	-2.548	.001	.006	3	3
LARGE_INTESTINE	COA7 →	+0.537	+3.169	.002	.006	3	2
LARGE_INTESTINE	ZNF669 →	+0.559	+2.628	<.001	.002	3	2
LARGE_INTESTINE	CD302 →	-0.859	-3.082	<.001	.006	3	2
LARGE_INTESTINE	FPGT →	+0.508	+3.234	<.001	.004	3	2
LUNG_NSCLC_LUAD	DPH2 →	+0.542	+2.621	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 332 associations by consensus.

CTNNA1 by DACH1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →