DAAM2

Across TCGA pan-cancer cohorts, DAAM2 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of DAAM2’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where DAAM2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types DAAM2 is over-expressed in tumor, although a few such as LSCC and LUAD show the opposite, repressed pattern.

LSCC, LUAD, and COAD are the cancer types where DAAM2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DAAM2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	All	−0.994	<.001	8	view →
LUAD	Male	III,IV	−0.736	<.001	8	view →
COAD	Male	All	−0.845	.002	4	view →
OV	All	All	−0.638	.036	2	view →
PDAC	All	All	−0.343	.028	1	view →
CCRCC	All	All	−0.162	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

DAAM2–LSCC

Open the LSCC breakdown →