DAAM2

Across TCGA patient cohorts, DAAM2 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DAAM2-associated genes across cancer lineages are PKC-a, eEF2, and ERCC1. Each is linked with DAAM2 in more than 3 cancer types. Because this analysis shows association rather than direction, both DAAM2-to-partner and partner-to-DAAM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-a grouped by DAAM2-low versus DAAM2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DAAM2→partner) and Y-score (partner→DAAM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PKC-a →	-0.187	-1.807	.045	.024	3	3
UCEC	eEF2 →	+0.251	+1.807	.018	.024	3	3
BRCA	ERCC1 →	+0.251	+3.015	.001	.020	3	2
BRCA	GAPDH →	+1.146	+3.000	<.001	.038	1	4
COAD	EGFR_pY1068 →	-0.313	-3.321	.003	.009	3	2
COAD	NF2 →	+0.204	+2.012	.001	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

PKC-a by DAAM2 expression — COAD

Explore this box plot interactively →