CZIB

Across TCGA pan-cancer cohorts, CZIB mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CZIB data layer compared with 20 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CZIB mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CZIB expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

UCEC, CCRCC, and LUAD are the cancer types where CZIB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	0.580	1.000	.006	28	view →
CCRCC	DFS	Median	III,IV	0.928	0.128	.014	17	view →
LUAD	DFS	Tertile	All	0.929	0.370	<.001	15	view →
PDAC	OS	Median	III,IV	0.788	0.381	.020	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CZIB–UCEC (OS)

Open the UCEC breakdown →