CZIB

Across TCGA patient cohorts, CZIB protein abundance is significantly associated with the RNA expression of many other genes, with 16,507 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CZIB-associated genes across cancer lineages are TLL1, RERG, and ABCA8. Each is linked with CZIB in more than 7 cancer types. Because this analysis shows association rather than direction, both CZIB-to-partner and partner-to-CZIB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CZIB versus TLL1 in CCRCC, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CZIB→partner) and Y-score (partner→CZIB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TLL1 →	+1.048	+0.162	<.001	<.001	3	8
UCEC	RERG →	+1.407	+0.283	<.001	<.001	3	7
UCEC	ABCA8 →	+1.172	+0.349	<.001	<.001	3	7
BRCA	ABCA6 →	+0.675	+0.254	<.001	<.001	3	7
BRCA	ZCCHC24 →	+1.140	+0.310	<.001	<.001	3	7
BRCA	KANK2 →	+0.817	+0.238	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,507 associations by consensus.

CZIB vs TLL1 — CCRCC

Explore this scatter interactively →