CZIB

Across TCGA patient cohorts, CZIB mutation is significantly associated with the RNA expression of many other genes, with 454 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CZIB-associated genes across cancer lineages are RN7SL140P, GPATCH11, and CLDND2. Each is linked with CZIB in more than 1 cancer types. Because this analysis shows association rather than direction, both CZIB-to-partner and partner-to-CZIB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL140P grouped by CZIB-low versus CZIB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CZIB→partner) and Y-score (partner→CZIB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL140P →	+0.111	+3.845	.002	.001	3	2
UCEC	GPATCH11 →	+0.523	+3.213	.004	.009	3	1
UCEC	CLDND2 →	+0.782	+3.595	<.001	.001	3	1
UCEC	KIAA1522 →	+0.796	+3.606	<.001	.001	3	1
UCEC	VANGL2 →	-0.910	-3.584	.006	.003	3	1
UCEC	C4orf3 →	+0.678	+3.617	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 454 associations by consensus.

RN7SL140P by CZIB expression — UCEC

Explore this box plot interactively →