CZIB

Across TCGA patient cohorts, CZIB mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CZIB-associated genes across cancer lineages are JNK_pT183_Y185, Caspase-8, and eIF4G. Each is linked with CZIB in more than 1 cancer types. Because this analysis shows association rather than direction, both CZIB-to-partner and partner-to-CZIB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by CZIB-low versus CZIB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CZIB→partner) and Y-score (partner→CZIB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.242	-2.986	.012	.037	3	1
UCEC	Caspase-8 →	-0.313	-3.000	.031	.037	3	1
UCEC	eIF4G →	+0.398	+3.000	.026	.037	2	1
UCEC	p62 Lck ligand →	+0.504	+3.009	.007	.019	2	1
UCEC	EGFR_pY1068 →	-0.380	-3.000	.008	.037	1	1
UCEC	STAT3_pY705 →	-0.553	-3.000	<.001	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

JNK_pT183_Y185 by CZIB expression — UCEC

Explore this box plot interactively →