CZIB

Across TCGA cell cohorts, CZIB RNA expression is significantly associated with the go_rna of many other GO terms, with 2,616 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CZIB-associated GO terms across cancer lineages are DNA biosynthetic process, Microtubule cytoskeleton organization involved in mitosis, and Phosphatidylinositol metabolic process. Each is linked with CZIB in more than 8 cancer types. Because this analysis shows association rather than direction, both CZIB-to-partner and partner-to-CZIB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA biosynthetic process grouped by CZIB-low versus CZIB-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CZIB→partner) and Y-score (partner→CZIB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA biosynthetic process →	+0.071	+0.796	.002	.001	3	9
BLOOD_Lymphoma	Microtubule cytoskeleton organization involved in mitosis →	+0.057	+0.363	.005	.009	3	9
LARGE_INTESTINE	Phosphatidylinositol metabolic process →	+0.025	+0.334	.008	.008	3	7
UPPER_AERODIGESTIVE_TRACT	Regulation of interleukin-6 production →	-0.084	-0.679	<.001	.007	3	7
BLOOD_Leukemia	Establishment of mitotic spindle orientation →	+0.059	+0.341	.001	<.001	3	7
BLOOD_Leukemia	Regulation of metaphase/anaphase transition of cell cycle →	+0.045	+0.313	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,616 associations by consensus.

DNA biosynthetic process by CZIB expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →