CYTH4

Across TCGA pan-cancer cohorts, CYTH4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CYTH4 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CYTH4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CYTH4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, LSCC, and GBM are the cancer types where CYTH4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	1.000	0.449	.033	18	view →
LSCC	OS	Quartile	III,IV	0.970	0.659	.024	6	view →
GBM	OS	Median	All	0.435	0.618	.024	4	view →
PDAC	OS	Median	II,III,IV	0.701	0.942	.012	4	view →
LUAD	DFS	Median	All	0.734	0.525	.023	4	view →
CCRCC	OS	Quartile	III,IV	0.611	1.000	.027	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CYTH4–HNSC (OS)

Open the HNSC breakdown →