CYTH4

Across TCGA cell cohorts, CYTH4 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CYTH4-associated genes across cancer lineages are FOXI2, DYTN, and HNRNPCL4. Each is linked with CYTH4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYTH4-to-partner and partner-to-CYTH4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXI2 grouped by CYTH4-low versus CYTH4-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYTH4→partner) and Y-score (partner→CYTH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FOXI2 →	+0.003	+2.777	<.001	.004	3	1
SKIN	DYTN →	+0.048	+3.310	.005	<.001	3	1
LARGE_INTESTINE	HNRNPCL4 →	+0.047	+3.793	.006	.007	3	1
LARGE_INTESTINE	MOG →	+0.140	+4.054	<.001	.004	3	1
LARGE_INTESTINE	GSG1L2 →	+0.016	+4.437	<.001	.004	3	1
SKIN	CLDN10 →	+0.270	+3.478	.008	.002	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

FOXI2 by CYTH4 expression — SKIN

Explore this box plot interactively →