CYTH3

Across TCGA pan-cancer cohorts, CYTH3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CYTH3 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CYTH3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CYTH3 expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

UCEC, PDAC, and GBM are the cancer types where CYTH3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.422	0.884	.012	26	view →
PDAC	OS	Quartile	III,IV	1.000	0.298	.006	18	view →
GBM	DFS	Tertile	All	0.439	0.214	.009	14	view →
LSCC	OS	Quartile	All	0.599	1.000	.010	9	view →
CCRCC	DFS	Quartile	III,IV	0.763	0.413	.020	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CYTH3–UCEC (OS)

Open the UCEC breakdown →