CYTH3

Across TCGA cell cohorts, CYTH3 mutation is significantly associated with the drug of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYTH3-associated genes across cancer lineages are Pevonedistat, CP466722, and GSK2801. Each is linked with CYTH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYTH3-to-partner and partner-to-CYTH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pevonedistat grouped by CYTH3-low versus CYTH3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYTH3→partner) and Y-score (partner→CYTH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Pevonedistat →	+0.818	+2.649	.017	.046	3	1
LARGE_INTESTINE	CP466722 →	+0.460	+2.652	.019	.045	3	1
LARGE_INTESTINE	GSK2801 →	+0.335	+2.649	.035	.046	3	1
LARGE_INTESTINE	SGC-CBP30 →	+0.286	+2.649	.043	.046	3	1
LARGE_INTESTINE	Wnt-C59 →	+0.364	+2.646	.038	.047	3	1
LARGE_INTESTINE	AGI-6780 →	+0.386	+2.646	.047	.047	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Pevonedistat by CYTH3 expression — LARGE_INTESTINE

Explore this box plot interactively →