CYTH2

Across TCGA patient cohorts, CYTH2 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYTH2-associated genes across cancer lineages are Bak, 14-3-3_beta, and EGFR_pY1068. Each is linked with CYTH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYTH2-to-partner and partner-to-CYTH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bak grouped by CYTH2-low versus CYTH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYTH2→partner) and Y-score (partner→CYTH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bak →	+0.209	+1.874	.038	.049	3	2
UCEC	14-3-3_beta →	-0.112	-3.432	.005	.005	3	1
UCEC	EGFR_pY1068 →	-0.216	-1.906	.032	.016	3	1
UCEC	Gab2 →	+0.352	+1.906	.014	.016	3	1
UCEC	INPP4B →	-0.311	-2.321	.016	.033	3	1
UCEC	JNK2 →	+0.193	+3.196	.015	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Bak by CYTH2 expression — UCEC

Explore this box plot interactively →