CYTH2

Across TCGA cell cohorts, CYTH2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CYTH2-associated genes across cancer lineages are BHLHA9, PROP1, and MORN5. Each is linked with CYTH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYTH2-to-partner and partner-to-CYTH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BHLHA9 grouped by CYTH2-low versus CYTH2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYTH2→partner) and Y-score (partner→CYTH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BHLHA9 →	+0.147	+4.095	.008	.009	3	1
BLOOD_Leukemia	PROP1 →	+0.018	+3.289	.004	.009	3	1
BLOOD_Leukemia	MORN5 →	+0.168	+4.177	<.001	.001	3	1
BLOOD_Leukemia	PLEKHS1 →	+0.074	+3.551	<.001	.008	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

BHLHA9 by CYTH2 expression — LARGE_INTESTINE

Explore this box plot interactively →