CYTH1

Across TCGA pan-cancer cohorts, CYTH1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated CYTH1 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CYTH1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CYTH1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, COAD, and CCRCC are the cancer types where CYTH1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	III,IV	1.000	0.177	.024	13	view →
COAD	DFS	Median	II,III,IV	0.912	1.000	.042	12	view →
CCRCC	DFS	Median	All	0.844	0.628	.006	10	view →
LSCC	DFS	Median	II,III,IV	1.000	0.829	.003	9	view →
UCEC	OS	Quartile	All	1.000	0.847	.035	6	view →
PDAC	DFS	Median	All	0.433	0.211	.009	5	view →
LUAD	DFS	Tertile	II,III,IV	0.839	0.446	.026	4	view →
GBM	OS	Median	All	0.892	0.816	.025	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

CYTH1–HNSC (OS)

Open the HNSC breakdown →