CYSTM1

Across TCGA patient cohorts, CYSTM1 mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYSTM1-associated genes across cancer lineages are CFC1B, CCDC103, and BNIP3P4. Each is linked with CYSTM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYSTM1-to-partner and partner-to-CYSTM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFC1B grouped by CYSTM1-low versus CYSTM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYSTM1→partner) and Y-score (partner→CYSTM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CFC1B →	+0.039	+4.555	<.001	.005	3	1
UCEC	CCDC103 →	+0.049	+4.432	<.001	<.001	3	1
UCEC	BNIP3P4 →	+0.082	+4.069	<.001	.002	3	1
UCEC	IGKV2OR2-2 →	+0.157	+3.344	.006	.008	3	1
UCEC	OR6K4P →	+0.104	+3.943	<.001	.002	3	1
UCEC	RNU6-668P →	+0.508	+4.356	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

CFC1B by CYSTM1 expression — UCEC

Explore this box plot interactively →