CYSLTR2

Across TCGA pan-cancer cohorts, CYSLTR2 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CYSLTR2 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CYSLTR2 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated CYSLTR2 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUAD, UCEC, and SCLC are the cancer types where CYSLTR2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	IV	0.194	0.734	<.001	42	view →
UCEC	DFS	Median	All	1.000	0.627	.011	24	view →
SCLC	OS	Median	All	0.082	0.708	<.001	12	view →
SARC	DFS	Median	All	0.173	0.612	.020	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CYSLTR2–LUAD (DFS)

Open the LUAD breakdown →