CYSLTR2

Across TCGA patient cohorts, CYSLTR2 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYSLTR2-associated genes across cancer lineages are eIF4E, eEF2, and EGFR_pY1068. Each is linked with CYSLTR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYSLTR2-to-partner and partner-to-CYSLTR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CYSLTR2-low versus CYSLTR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYSLTR2→partner) and Y-score (partner→CYSLTR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.248	+3.713	.001	<.001	3	2
UCEC	eEF2 →	+0.384	+1.502	.003	.030	3	1
UCEC	EGFR_pY1068 →	-0.297	-3.807	.001	<.001	3	1
UCEC	ERK2 →	+0.141	+2.321	.046	.033	3	1
UCEC	FASN →	+0.408	+1.700	.004	.042	3	1
UCEC	GAPDH →	+0.707	+3.807	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

eIF4E by CYSLTR2 expression — UCEC

Explore this box plot interactively →