CYREN

Across TCGA pan-cancer cohorts, CYREN Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated CYREN data layer compared with 24 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CYREN Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CYREN expression acts as an unfavorable survival marker, although some lineages such as STAD show a favorable association.

COAD and STAD are the cancer types where CYREN Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.150	0.809	<.001	12	view →
STAD	OS	Median	IV	1.000	0.299	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

CYREN–COAD (OS)

Open the COAD breakdown →