CYREN

Across TCGA patient cohorts, CYREN mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYREN-associated genes across cancer lineages are ATM, Cyclin-B1, and FOXO3a_pS318_S321. Each is linked with CYREN in more than 1 cancer types. Because this analysis shows association rather than direction, both CYREN-to-partner and partner-to-CYREN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CYREN-low versus CYREN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYREN→partner) and Y-score (partner→CYREN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.675	-3.000	.009	.037	1	2
UCEC	Cyclin-B1 →	+0.829	+3.000	.010	.037	2	1
UCEC	FOXO3a_pS318_S321 →	-0.147	-3.000	.042	.037	1	1
UCEC	Ku80 →	+0.336	+3.013	.013	.019	1	1
UCEC	Caspase-7-cleavedD198 →	+1.279	+3.000	<.001	.037	1	1
UCEC	4E-BP1 →	+0.394	+3.000	.011	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ATM by CYREN expression — UCEC

Explore this box plot interactively →