CYREN

Across TCGA cell cohorts, CYREN RNA expression is significantly associated with the go_rna of many other GO terms, with 3,901 significant associations in total. CNS shows the largest number of these associations.

The most reproducible CYREN-associated GO terms across cancer lineages are Positive regulation of double-strand break repair, Positive regulation of DNA recombination, and RNA export from nucleus. Each is linked with CYREN in more than 11 cancer types. Because this analysis shows association rather than direction, both CYREN-to-partner and partner-to-CYREN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of double-strand break repair grouped by CYREN-low versus CYREN-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYREN→partner) and Y-score (partner→CYREN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of double-strand break repair →	+0.090	+0.745	<.001	<.001	3	12
BREAST	Positive regulation of DNA recombination →	+0.069	+0.972	<.001	<.001	3	12
SOFT_TISSUE	RNA export from nucleus →	+0.143	+0.922	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Positive regulation of isotype switching to IgG isotypes →	+0.163	+0.916	.001	.004	2	12
LUNG_NSCLC_LUSC	Interstrand cross-link repair →	+0.078	+1.118	.005	<.001	3	11
SOFT_TISSUE	Nuclear export →	+0.108	+0.922	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,901 associations by consensus.

Positive regulation of double-strand break repair by CYREN expression — SOFT_TISSUE

Explore this box plot interactively →