CYP7B1

Across TCGA pan-cancer cohorts, CYP7B1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of CYP7B1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CYP7B1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CYP7B1 is over-expressed in tumor, although a few such as HNSC and CCRCC show the opposite, repressed pattern.

HNSC, CCRCC, and PDAC are the cancer types where CYP7B1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYP7B1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	−0.525	<.001	11	view →
CCRCC	All	III,IV	−0.316	<.001	9	view →
PDAC	Male	All	−0.698	<.001	6	view →
LUAD	All	All	+0.180	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

CYP7B1–HNSC

Open the HNSC breakdown →