CYP7B1

Across TCGA patient cohorts, CYP7B1 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP7B1-associated genes across cancer lineages are c-Kit, p38-MAPK_pT180_Y182, and Cyclin-E2. Each is linked with CYP7B1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CYP7B1-to-partner and partner-to-CYP7B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Kit grouped by CYP7B1-low versus CYP7B1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP7B1→partner) and Y-score (partner→CYP7B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	c-Kit →	-0.599	-2.459	.014	.018	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.358	-1.446	.014	.012	3	3
UCEC	Cyclin-E2 →	+0.124	+1.716	.022	.003	3	3
COAD	JNK_pT183_Y185 →	-0.268	-3.169	.022	.018	3	2
COAD	ASNS →	+0.577	+2.330	.001	.020	3	2
UCEC	C-Raf →	+0.179	+2.662	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

c-Kit by CYP7B1 expression — SKCM

Explore this box plot interactively →