CYP7B1

Across TCGA cell cohorts, CYP7B1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,004 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CYP7B1-associated GO terms across cancer lineages are Lysosomal lumen acidification, Cholesterol metabolic process, and Eye photoreceptor cell differentiation. Each is linked with CYP7B1 in more than 6 cancer types. Because this analysis shows association rather than direction, both CYP7B1-to-partner and partner-to-CYP7B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lysosomal lumen acidification grouped by CYP7B1-low versus CYP7B1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP7B1→partner) and Y-score (partner→CYP7B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Lysosomal lumen acidification →	+0.083	+1.110	.001	.004	3	7
LUNG_SCLC	Cholesterol metabolic process →	+0.086	+1.291	.001	<.001	3	7
SKIN	Eye photoreceptor cell differentiation →	-0.054	-1.273	<.001	<.001	3	6
SKIN	Viral process →	+0.055	+1.181	.001	.006	1	7
BLOOD_Leukemia	Primary amino compound catabolic process →	-0.108	-0.531	<.001	.002	3	5
BLOOD_Leukemia	Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator →	+0.074	+0.844	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,004 associations by consensus.

Lysosomal lumen acidification by CYP7B1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →