CYP7B1

Across TCGA cell cohorts, CYP7B1 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CYP7B1-associated genes across cancer lineages are KRTAP1-4, MS4A12, and OR4C3. Each is linked with CYP7B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP7B1-to-partner and partner-to-CYP7B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP1-4 grouped by CYP7B1-low versus CYP7B1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP7B1→partner) and Y-score (partner→CYP7B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	KRTAP1-4 →	+0.143	+4.906	<.001	.006	3	1
OESOPHAGUS	MS4A12 →	+0.043	+4.906	<.001	.006	3	1
LUNG_SCLC	OR4C3 →	+0.073	+5.643	<.001	.002	3	1
LUNG_NSCLC_LUAD	RCVRN →	+0.113	+3.918	<.001	.001	3	1
LUNG_NSCLC_LUAD	RTP3 →	+0.547	+2.951	<.001	.004	3	1
LUNG_NSCLC_LUAD	XIRP1 →	+0.013	+3.361	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

KRTAP1-4 by CYP7B1 expression — OESOPHAGUS

Explore this box plot interactively →