CYP51A1

Across TCGA pan-cancer cohorts, CYP51A1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CYP51A1 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CYP51A1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CYP51A1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, OV, and GBM are the cancer types where CYP51A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.938	0.627	<.001	22	view →
OV	DFS	Median	All	0.604	0.874	.037	4	view →
GBM	DFS	Median	All	0.246	0.478	.013	4	view →
LSCC	OS	Quartile	All	0.936	0.800	.033	3	view →
PDAC	OS	Tertile	IV	0.472	0.962	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CYP51A1–CCRCC (DFS)

Open the CCRCC breakdown →