CYP51A1

Across TCGA pan-cancer cohorts, CYP51A1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CYP51A1’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where CYP51A1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CYP51A1 is over-expressed in tumor, although a few such as CCRCC and LSCC show the opposite, repressed pattern.

CCRCC, LSCC, and COAD are the cancer types where CYP51A1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYP51A1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	IV	−1.083	<.001	12	view →
LSCC	Female	II,III,IV	−0.824	<.001	8	view →
COAD	All	All	+0.225	<.001	8	view →
LUAD	Male	III,IV	−0.666	<.001	7	view →
PDAC	All	All	−0.548	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CYP51A1–CCRCC

Open the CCRCC breakdown →