CYP51A1

Across TCGA patient cohorts, CYP51A1 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,439 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CYP51A1-associated proteins across cancer lineages are FDFT1, HMGCS1, and IL4I1. Each is linked with CYP51A1 in more than 5 cancer types. Because this analysis shows association rather than direction, both CYP51A1-to-partner and partner-to-CYP51A1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CYP51A1 versus FDFT1 in LSCC, with a Pearson correlation of 0.34.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP51A1→partner) and Y-score (partner→CYP51A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FDFT1 →	+0.897	+0.628	<.001	<.001	3	6
LSCC	HMGCS1 →	+0.943	+0.831	<.001	<.001	3	6
GBM	IL4I1 →	-0.662	-0.388	<.001	.001	3	6
HNSC	WAS →	-0.457	-0.971	<.001	<.001	3	5
OV	MSMO1 →	+0.523	+0.460	.006	.005	3	5
LSCC	MVK →	+0.495	+0.686	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,439 associations by consensus.

CYP51A1 vs FDFT1 — LSCC

Explore this scatter interactively →