CYP51A1

Across TCGA patient cohorts, CYP51A1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP51A1-associated genes across cancer lineages are PCNA, EGFR_pY1068, and FoxM1. Each is linked with CYP51A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP51A1-to-partner and partner-to-CYP51A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by CYP51A1-low versus CYP51A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP51A1→partner) and Y-score (partner→CYP51A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.279	+2.999	.003	.035	3	2
UCEC	EGFR_pY1068 →	-0.249	-2.115	.023	.019	3	1
UCEC	FoxM1 →	+0.247	+2.817	.029	.036	3	1
UCEC	INPP4B →	-0.296	-3.459	.036	.005	3	1
UCEC	JNK2 →	+0.308	+2.331	<.001	.019	3	1
UCEC	Ku80 →	+0.251	+2.820	.015	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

PCNA by CYP51A1 expression — UCEC

Explore this box plot interactively →