CYP51A1

Across TCGA cell cohorts, CYP51A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,385 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CYP51A1-associated GO terms across cancer lineages are Sterol biosynthetic process, Secondary alcohol biosynthetic process, and Cholesterol biosynthetic process via desmosterol. Each is linked with CYP51A1 in more than 17 cancer types. Because this analysis shows association rather than direction, both CYP51A1-to-partner and partner-to-CYP51A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sterol biosynthetic process grouped by CYP51A1-low versus CYP51A1-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP51A1→partner) and Y-score (partner→CYP51A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Sterol biosynthetic process →	+0.196	+1.211	<.001	<.001	3	18
LUNG_SCLC	Secondary alcohol biosynthetic process →	+0.221	+1.123	<.001	<.001	3	17
BONE	Cholesterol biosynthetic process via desmosterol →	+0.197	+1.059	<.001	<.001	3	17
OVARY	Zymosterol metabolic process →	+0.218	+1.315	<.001	<.001	3	17
OVARY	Zymosterol biosynthetic process →	+0.218	+1.315	<.001	<.001	3	17
LUNG_NSCLC_LUAD	Steroid biosynthetic process →	+0.145	+0.886	<.001	.003	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,385 associations by consensus.

Sterol biosynthetic process by CYP51A1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →