CYP51A1

Across TCGA cell cohorts, CYP51A1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CYP51A1-associated genes across cancer lineages are NEU2, SPDYE4, and OR52M1. Each is linked with CYP51A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP51A1-to-partner and partner-to-CYP51A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NEU2 grouped by CYP51A1-low versus CYP51A1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP51A1→partner) and Y-score (partner→CYP51A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	NEU2 →	+0.020	+5.643	<.001	.002	3	1
LUNG_SCLC	SPDYE4 →	+0.055	+5.029	.008	.006	3	1
LUNG_SCLC	OR52M1 →	+0.025	+5.029	<.001	.006	3	1
BLOOD_Leukemia	PRAMEF7 →	+0.022	+4.539	<.001	.007	3	1
LARGE_INTESTINE	KRT85 →	+0.468	+3.823	<.001	.006	3	1
LARGE_INTESTINE	MMP26 →	+0.039	+3.632	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

NEU2 by CYP51A1 expression — LUNG_SCLC

Explore this box plot interactively →