Across TCGA pan-cancer cohorts, CYP4Z1 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CYP4Z1 data layer compared with 25 for mass-spec protein.
The strongest signal is observed in breast invasive carcinoma (BRCA), where higher CYP4Z1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CYP4Z1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.
BRCA, SARC, and OV are the cancer types where CYP4Z1 Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.