CYP4Z1

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, CYP4Z1 mutation is significantly associated with the RNA expression of many other genes, with 3,735 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP4Z1-associated genes across cancer lineages are RN7SL414P, ZFYVE19, and GPX4. Each is linked with CYP4Z1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP4Z1-to-partner and partner-to-CYP4Z1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP4Z1→partner) and Y-score (partner→CYP4Z1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CESCRN7SL414P →+0.247+5.103<.001.00832
UCECZFYVE19 →+0.405+2.194<.001.00132
UCECGPX4 →+0.398+2.316.004<.00132
UCECUBXN6 →+0.317+2.462.003.00132
SKCMPRELID1 →+0.282+2.239<.001<.00132
SKCMCRADD →+0.382+1.631.002.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 3,735 associations by consensus.

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