CYP4Z1

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, CYP4Z1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP4Z1-associated genes across cancer lineages are EGFR, MYH11, and JNK_pT183_Y185. Each is linked with CYP4Z1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP4Z1-to-partner and partner-to-CYP4Z1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP4Z1→partner) and Y-score (partner→CYP4Z1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECEGFR →-0.154-2.973.008.03532
SKCMMYH11 →-0.546-1.502.038.02532
UCECJNK_pT183_Y185 →-0.165-2.115.007.01732
UCECMEK1 →+0.450+3.700<.001.00132
UCECPCNA →+0.282+2.736<.001<.00132
UCECCaspase-7-cleavedD198 →+0.765+2.242<.001.00532
Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Exploration