Across TCGA cell cohorts, CYP4Z1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CYP4Z1-associated genes across cancer lineages are DEFA1, CD300H, and ODF1. Each is linked with CYP4Z1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP4Z1-to-partner and partner-to-CYP4Z1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP4Z1→partner) and Y-score (partner→CYP4Z1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	DEFA1 →	+0.443	+5.000	<.001	.005	3	1
LARGE_INTESTINE	CD300H →	+0.045	+5.415	<.001	.004	3	1
SKIN	ODF1 →	+0.013	+4.022	<.001	.006	3	1
SKIN	OR51J1 →	+0.069	+3.347	<.001	.005	3	1
SKIN	H2AB1 →	+0.411	+4.000	<.001	.002	3	1
SKIN	ZSCAN10 →	+0.088	+3.766	.003	.004	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

CYP4Z1 survival (RNA) · tumor vs normal (RNA) · all CYP4Z1 data types