CYP4V2

Across TCGA pan-cancer cohorts, CYP4V2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CYP4V2 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CYP4V2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CYP4V2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, LSCC, and PDAC are the cancer types where CYP4V2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.751	0.409	.002	26	view →
LSCC	DFS	Median	III,IV	0.868	0.359	.006	20	view →
PDAC	DFS	Tertile	All	0.452	0.873	.024	7	view →
LUAD	DFS	Median	III,IV	0.922	0.409	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CYP4V2–CCRCC (DFS)

Open the CCRCC breakdown →