CYP4V2

Across TCGA patient cohorts, CYP4V2 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP4V2-associated genes across cancer lineages are eIF4E, MEK1, and Notch1. Each is linked with CYP4V2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP4V2-to-partner and partner-to-CYP4V2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CYP4V2-low versus CYP4V2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP4V2→partner) and Y-score (partner→CYP4V2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.224	+3.472	.005	.002	3	2
UCEC	MEK1 →	+0.333	+2.222	.017	.010	3	2
UCEC	Notch1 →	+0.186	+1.678	<.001	.023	3	2
UCEC	ATM →	-0.381	-1.678	.028	.023	3	2
UCEC	C-Raf →	+0.162	+1.678	.003	.023	3	2
UCEC	EGFR_pY1068 →	-0.252	-2.584	.008	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

eIF4E by CYP4V2 expression — UCEC

Explore this box plot interactively →