CYP4V2

Across TCGA cell cohorts, CYP4V2 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CYP4V2-associated genes across cancer lineages are IFNA7, PRAMEF18, and AVP. Each is linked with CYP4V2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP4V2-to-partner and partner-to-CYP4V2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA7 grouped by CYP4V2-low versus CYP4V2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP4V2→partner) and Y-score (partner→CYP4V2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	IFNA7 →	+0.020	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	PRAMEF18 →	+0.003	+4.058	<.001	.009	3	1
LARGE_INTESTINE	AVP →	+0.068	+4.217	<.001	.001	3	1
LARGE_INTESTINE	HNRNPCL4 →	+0.051	+3.793	.003	.007	3	1
LARGE_INTESTINE	LRRC3C →	+0.352	+3.777	<.001	.007	3	1
LUNG_NSCLC_LUAD	FAM181A →	+0.045	+4.266	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

IFNA7 by CYP4V2 expression — BLOOD_Lymphoma

Explore this box plot interactively →