CYP4V2

Across TCGA cell cohorts, CYP4V2 mutation is significantly associated with the mutation status of many other genes, with 2,596 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYP4V2-associated genes across cancer lineages are LAMC3, ODF2, and THSD7B. Each is linked with CYP4V2 in more than 3 cancer types. Because this analysis shows association rather than direction, both CYP4V2-to-partner and partner-to-CYP4V2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LAMC3 grouped by CYP4V2-low versus CYP4V2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP4V2→partner) and Y-score (partner→CYP4V2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	LAMC3 →	+5.415	+5.415	.004	.004	1	4
OVARY	ODF2 →	+5.415	+5.415	.004	.004	1	4
SKIN	THSD7B →	+1.795	+3.838	.002	.002	1	4
CNS	NRP2 →	+5.044	+5.614	.003	.003	1	4
OVARY	SAFB2 →	+4.415	+4.977	.007	.007	1	4
OVARY	RFX1 →	+4.415	+4.977	.007	.007	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,596 associations by consensus.

LAMC3 by CYP4V2 expression — OVARY

Explore this box plot interactively →