Across TCGA patient cohorts, CYP4F3 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP4F3-associated genes across cancer lineages are Chk1, 4E-BP1, and ASNS. Each is linked with CYP4F3 in more than 2 cancer types. Because this analysis shows association rather than direction, both CYP4F3-to-partner and partner-to-CYP4F3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP4F3→partner) and Y-score (partner→CYP4F3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Chk1 →	+0.133	+1.619	.037	.005	3	3
UCEC	4E-BP1 →	+0.283	+3.459	.002	.005	3	3
UCEC	ASNS →	+0.381	+1.514	.001	.015	3	3
LUAD	Bim →	+0.323	+3.169	.027	.019	3	2
STAD	Cyclin-E2 →	+0.220	+3.190	<.001	.009	3	2
SKCM	YAP_pS127 →	-0.280	-2.087	.019	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

Exploration

CYP4F3 survival (RNA) · tumor vs normal (RNA) · all CYP4F3 data types