CYP4F22

Across TCGA patient cohorts, CYP4F22 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP4F22-associated genes across cancer lineages are ASNS, PCNA, and Bad_pS112. Each is linked with CYP4F22 in more than 3 cancer types. Because this analysis shows association rather than direction, both CYP4F22-to-partner and partner-to-CYP4F22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by CYP4F22-low versus CYP4F22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP4F22→partner) and Y-score (partner→CYP4F22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.345	+1.765	.002	.013	3	4
UCEC	PCNA →	+0.153	+1.137	.025	.041	3	2
UCEC	Bad_pS112 →	-0.137	-1.986	.019	.029	3	2
UCEC	Caspase-7-cleavedD198 →	+0.385	+1.522	.039	.017	3	2
UCEC	4E-BP1 →	+0.225	+1.353	.008	.015	3	2
SKCM	Rb →	-0.143	-2.000	.045	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

ASNS by CYP4F22 expression — UCEC

Explore this box plot interactively →