Across TCGA pan-cancer cohorts, CYP4F12 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of CYP4F12’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CYP4F12 RNA is repressed in tumor relative to normal tissue. In most cancer types CYP4F12 is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.
HNSC, COAD, and KICH are the cancer types where CYP4F12 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYP4F12 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.