CYP4F11

Across TCGA patient cohorts, CYP4F11 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP4F11-associated genes across cancer lineages are eIF4E, Shc_pY317, and VEGFR2. Each is linked with CYP4F11 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP4F11-to-partner and partner-to-CYP4F11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CYP4F11-low versus CYP4F11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP4F11→partner) and Y-score (partner→CYP4F11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.145	+3.820	.026	<.001	3	2
UCEC	Shc_pY317 →	-0.139	-1.415	.003	.010	3	2
UCEC	VEGFR2 →	+0.272	+1.428	.003	.006	3	2
UCEC	ATM →	-0.389	-1.893	.005	.014	3	2
UCEC	Cyclin-B1 →	+0.590	+2.169	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.098	-1.821	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

eIF4E by CYP4F11 expression — UCEC

Explore this box plot interactively →