CYP4F11

Across TCGA cell cohorts, CYP4F11 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CYP4F11-associated genes across cancer lineages are MAGEB4, ADAM2, and SPINT4. Each is linked with CYP4F11 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP4F11-to-partner and partner-to-CYP4F11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by CYP4F11-low versus CYP4F11-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP4F11→partner) and Y-score (partner→CYP4F11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.012	+5.415	.009	.004	3	1
SKIN	ADAM2 →	+0.006	+6.022	<.001	.001	3	1
LUNG_NSCLC_LUAD	SPINT4 →	+0.047	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR14C36 →	+0.020	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	HIGD1C →	+0.084	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	IQCF3 →	+0.042	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

MAGEB4 by CYP4F11 expression — LARGE_INTESTINE

Explore this box plot interactively →