CYP4F11

Across TCGA cell cohorts, CYP4F11 mutation is significantly associated with the mutation status of many other genes, with 1,588 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CYP4F11-associated genes across cancer lineages are LGI4, FMNL2, and SPRED1. Each is linked with CYP4F11 in more than 2 cancer types. Because this analysis shows association rather than direction, both CYP4F11-to-partner and partner-to-CYP4F11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LGI4 grouped by CYP4F11-low versus CYP4F11-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP4F11→partner) and Y-score (partner→CYP4F11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LGI4 →	+3.635	+3.635	.003	.003	1	3
BLOOD_Leukemia	FMNL2 →	+4.635	+4.145	.001	.001	1	3
BLOOD_Leukemia	SPRED1 →	+5.050	+4.000	.008	.008	1	3
LUNG_NSCLC_LUAD	ALDH16A1 →	+4.772	+5.339	.004	.004	1	3
LUNG_NSCLC_LUAD	IBTK →	+5.772	+5.772	.002	.002	1	3
BLOOD_Leukemia	KDM5A →	+3.243	+3.762	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,588 associations by consensus.

LGI4 by CYP4F11 expression — BLOOD_Leukemia

Explore this box plot interactively →